Raiders vs. Bills odds: Opening lines for Week 6 matchup

· Yahoo Sports

FOXBOROUGH, MASSACHUSETTS - OCTOBER 11: Fernando Mendoza #15 of the Las Vegas Raiders scrambles and runs with the ball against the New England Patriots during an NFL football game at Gillette Stadium on October 11, 2026 in Foxborough, Massachusetts. (Photo by Michael Owens/Getty Images) | Getty Images

The Las Vegas Raiders have lost two straight after a 3-0 start. This time, it was an embarrassing road loss to the New England Patriots, 45-17.

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The Raiders will be back home next Sunday to face the Buffalo Bills. They will attempt to stop the bleeding against one of the best teams in football. They will need a bounce-back on offense and defense to do it. Hopefully, they can get healthy during the week and catch a team off guard for an upset.

Fanduel Sportsbook posted odds for all the games of the third week of the season. The Raiders are 5.5-point underdogs against the Buffalo Bills, with an over/under (O/U) of 45.5.

With two teams on a bye in Week 5, plenty of NFL action is coming. FanDuel lists the New England Patriots as the biggest favorites in the upcoming games, at -7.5 over the New York Jets.

Raiders vs. Bills

Moneyline: Bills -275, Raiders +225

Opening point spread: 5.5

Opening point total: 52.5

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